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ROME — Pope Francis suffered an isolated coughing fit on Friday that resulted in him inhaling vomit, requiring non-invasive mechanical ventilation, the Vatican said in relaying a setback in his two-week long battle against double pneumonia.

The 88-year-old pope remained conscious and alert at all times and cooperated with the maneuvers to help him recover. He responded well, with a good level of oxygen exchange and was continuing to wear a mask to receive supplemental oxygen, the Vatican said.

The development marked a setback in what had been two successive days of increasingly upbeat reports from doctors treating Francis at Rome’s Gemelli hospital since Feb. 14.