The Pan Amer­i­can Health Or­ga­ni­za­tion (PA­HO) has re­leased new clin­i­cal guide­lines for the man­age­ment of pa­tients with se­vere yel­low fever in the Amer­i­c­as, in­clud­ing the Caribbean.

The guide­lines come amidst the con­cerns that the dis­ease has re-emerged as a grow­ing pub­lic health mat­ter, with PA­HO not­ing that since 2024, out­breaks have been re­port­ed in sev­er­al coun­tries—in­clud­ing in ar­eas out­side the tra­di­tion­al Ama­zon basin—con­firm­ing an ex­pan­sion of risk zones.

Last year, PA­HO said a to­tal of 346 con­firmed cas­es and 143 deaths were re­port­ed across sev­en coun­tries in the re­gion, name­ly Bo­livia, Brazil, Colom­bia, Ecuador, Guyana, Pe­ru, and Venezuela.