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The Supreme Court struck down Pres­i­dent Don­ald Trump’s far-reach­ing glob­al tar­iffs on Fri­day, hand­ing him a sig­nif­i­cant loss on an is­sue cru­cial to his eco­nom­ic agen­da.

The 6-3 de­ci­sion cen­tres on tar­iffs im­posed un­der an emer­gency pow­ers law, in­clud­ing the sweep­ing “rec­i­p­ro­cal” tar­iffs he levied on near­ly every oth­er coun­try.

It’s the first ma­jor piece of Trump’s broad agen­da to come square­ly be­fore the na­tion’s high­est court, which he helped shape with the ap­point­ments of three con­ser­v­a­tive ju­rists in his first term.