Plunged in­to a gov­ern­ment shut­down, the U.S. is con­fronting a fresh cy­cle of un­cer­tain­ty af­ter Pres­i­dent Don­ald Trump and Con­gress failed to strike an agree­ment to keep gov­ern­ment pro­grams and ser­vices run­ning by Wednes­day’s dead­line.

Rough­ly 750,000 fed­er­al work­ers are ex­pect­ed to be fur­loughed, some po­ten­tial­ly fired by Trump’s Re­pub­li­can ad­min­is­tra­tion. Many of­fices will be shut­tered, per­haps per­ma­nent­ly, as Trump vows to “do things that are ir­re­versible, that are bad” as ret­ri­bu­tion. His de­por­ta­tion agen­da is ex­pect­ed to run full speed ahead, while ed­u­ca­tion, en­vi­ron­men­tal and oth­er ser­vices sput­ter. The eco­nom­ic fall­out is ex­pect­ed to rip­ple na­tion­wide.

The pres­i­dent ap­peared un­able to ne­go­ti­ate any deal be­tween De­moc­rats and Re­pub­li­cans to pre­vent the shut­down. This is the third time Trump has presided over a fed­er­al fund­ing lapse.