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Venezuelan President Nicolás Maduro believes that Prime Minister Kamla Persad-Bissessar has "lost her mind" over her comments in support of US military presence in the southern Caribbean.

Speaking at a press conference in Caracas on September 15, Maduro responded to a question about recent statements made by Venezuelan Defence Minister Vladimir Padrino López.

"I do not know what substances she is on," he said in a sharp rebuke that signals rising diplomatic tension.