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The U.S. and Is­rael launched a ma­jor at­tack on Iran on Sat­ur­day, with Pres­i­dent Don­ald Trump call­ing on the Iran­ian pub­lic to “seize con­trol of your des­tiny” and rise up against the Is­lam­ic lead­er­ship that has ruled the na­tion since 1979.

Some of the first strikes ap­peared to hit ar­eas around the of­fices of Supreme Leader Ay­a­tol­lah Ali Khamenei, and Iran­ian me­dia re­port­ed strikes na­tion­wide. Smoke could be seen ris­ing from the cap­i­tal. It wasn’t im­me­di­ate­ly clear whether the 86-year-old leader was in his of­fices at the time of the strike.

“When we are fin­ished, take over your gov­ern­ment. It will be yours to take. This will be prob­a­bly your on­ly chance for gen­er­a­tions,” Trump said in a video an­nounc­ing “ma­jor com­bat op­er­a­tions” were un­der­way. “For many years, you have asked for Amer­i­ca’s help, but you nev­er got it.”