(AP) — Formidable title favourite Jannick Sinner is out the French Open in the second round.

He lost to 56th-ranked Juan Manuel Cerundolo 3-6, 2-6, 7-5, 6-1, 6-1 while struggling with the heat and wasting a chance to serve for the match on Thursday.

Sinner was on a 30-match winning streak stretching back to February and the odds were overwhelming he'd complete a career Grand Slam by winning the only big title missing in his tennis career — especially with two-time reigning champion Carlos Alcaraz out due to an injured right wrist.